The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2023
Filed:
Jan. 02, 2019
Cas Lamvac (Guangzhou) Biomedical Technology Co., Ltd., Guangzhou, CN;
Hongxing Wang, Guangzhou, CN;
Shuanghong Liang, Guangzhou, CN;
Yinzhou Fan, Guangzhou, CN;
Zhenping Huang, Guangzhou, CN;
Siting Zhao, Guangzhou, CN;
Li Qin, Guangzhou, CN;
Xiaoping Chen, Guangzhou, CN;
CAS Lamvac (Guangzhou) Biomedical Technology Co., Ltd., Guangzhou, CN;
Abstract
Hot-melt extrusion for producing solid solution comprising nanoparticle formulation of decoquinate is disclosed. Aqueous phase comprising the nanoparticles of hot-melt extruding products is homogeneous and stable. Provided is the composition comprising the solid solution of decoquinate and a method of hot-melt extrusion for producing this composition comprising the solid dispersion of decoquinate. Furthermore, provided is the solid solution comprising nanosized decoquinate formulation having improved water solubility and enhanced delivery of decoquinate in digestive system for absorption, increasing bioavailability, and the efficacy against malaria at the liver stage.