The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2023
Filed:
Apr. 21, 2015
Rinat Neuroscience Corp., South San Francisco, CA (US);
Pfizer Inc., New York, NY (US);
Pavel Strop, San Mateo, CA (US);
Katherine Anne Delaria, Walnut Creek, CA (US);
Magdalena Dorywalska, Redwood City, CA (US);
Davide Luciano Foletti, Menlo Park, CA (US);
Russell George Dushin, Old Lyme, CT (US);
David Louis Shelton, Oakland, CA (US);
Arvind Rajpal, San Francisco, CA (US);
RINAT NEUROSCIENCE CORP., South San Francisco, CA (US);
PFIZER INC., New York, NY (US);
Abstract
The present invention provides transglutaminase-mediated antibody-drug conjugates with high anti-body-drug ratio (DAR) comprising 1) glutamine-containing tags, endogenous glutamines, and/or endogenous glutamines made reactive by antibody engineering or an engineered transglutaminase (e.g., with altered substrate specifity); and 2) amine donor agents comprising amine donor units, linkers, and agent moieties, wherein the DAR is at least about 5. The invention also provides methods of making and methods of using such higher drug loaded antibody-drug conjugates.