The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2023
Filed:
May. 11, 2020
Applicant:
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Inventors:
Eric R. Schreiter, Ashburn, VA (US);
Ahmed Abdelfattah, Ashburn, VA (US);
Assignee:
HOWARD HUGHES MEDICAL INSTITUTE, Chevy Chase, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
G01R 15/22 (2006.01); G01R 19/00 (2006.01); C07K 14/435 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
G01R 15/22 (2013.01); G01R 19/0084 (2013.01); C07K 14/43504 (2013.01); C07K 2319/60 (2013.01); G01N 21/6486 (2013.01);
Abstract
A voltage indicator includes a polypeptide sequence comprising a voltage-sensitive opsin domain and a capture protein domain arranged and disposed to capture a fluorescent dye ligand. When the fluorescent dye ligand is captured and the voltage indicator is bound to a cell membrane, an increase in voltage across the cell membrane causes an increase in fluorescent emission.