The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 07, 2023

Filed:

Jun. 18, 2021
Applicant:

University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);

Inventors:

Larisa J. Geskin, Riverdale, NY (US);

Brittany Lynn O'Neill Dulmage, Pittsburgh, PA (US);

Louis D. Falo, Jr., Pittsburgh, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/395 (2006.01); G01N 33/574 (2006.01); A61K 31/192 (2006.01); A61K 31/519 (2006.01); A61N 5/10 (2006.01); A61N 5/06 (2006.01); C12Q 1/6886 (2018.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
G01N 33/57426 (2013.01); A61K 31/192 (2013.01); A61K 31/395 (2013.01); A61K 31/519 (2013.01); A61N 5/062 (2013.01); A61N 5/10 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57407 (2013.01); A61N 2005/0661 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01);
Abstract

The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment.


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