The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2023
Filed:
Mar. 13, 2019
National University Corporation Tokyo Medical and Dental University, Tokyo, JP;
Takeda Pharmaceutical Company Limited, Osaka, JP;
Takanori Yokota, Tokyo, JP;
Tetsuya Nagata, Tokyo, JP;
Hideki Furukawa, Kanagawa, JP;
Yasuo Nakagawa, Kanagawa, JP;
Takatoshi Yogo, Kanagawa, JP;
Ryosuke Tokunoh, Kanagawa, JP;
Shigekazu Sasaki, Kanagawa, JP;
Kosuke Hidaka, Kanagawa, JP;
Tomohiro Seki, Kanagawa, JP;
Kenichi Miyata, Kanagawa, JP;
Akio Uchida, Kanagawa, JP;
Abstract
Developed and provided is: a nucleic acid agent that is efficiently delivered to the central nervous system, to which drug delivery is inhibited by the blood brain barrier mechanism, and that provides an antisense effect to a target transcription product at the delivery site; and a composition containing such a nucleic acid agent. Provided is a double-stranded nucleic acid complex consisting of a first nucleic acid strand and a second nucleic acid strand that are annealed to each other; wherein the first nucleic acid strand hybridizes with part of a target transcription product and has an antisense effect on the target transcription product; and wherein the second nucleic acid strand includes a base sequence complementary to the first nucleic acid strand and is conjugated to a phosphatidylethanolamine or an analog thereof.