The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2023
Filed:
Feb. 02, 2018
Applicants:
Antidote Therapeutics, Inc., Sykesville, MD (US);
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Matthew W. Kalnik, Bethesda, MD (US);
Thomas Thisted, New Market, MD (US);
Everett Stone, Austin, TX (US);
Charles C. Reed, Souderton, PA (US);
Max Rodnick-Smith, Austin, TX (US);
Assignees:
ANTIDOTE THERAPEUTICS, INC., Bethesda, MD (US);
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/00 (2006.01); C12N 9/04 (2006.01); A61K 47/60 (2017.01); A61P 43/00 (2006.01); C12N 9/02 (2006.01);
U.S. Cl.
CPC ...
C12N 9/0006 (2013.01); A61K 47/60 (2017.08); A61P 43/00 (2018.01); C12N 9/0004 (2013.01);
Abstract
Described are nicotine-degrading enzyme variants that exhibit increased nicotine-degrading activity and/or decreased immunogenicity relative to the wild-type NicA2 and NOX enzymes, compositions comprising the variants, and methods using them.