The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2023
Filed:
Apr. 30, 2021
Applicant:
Aetio Biotherapy, Inc., Dallas, TX (US);
Assignee:
Immune Targeting, Inc., Dallas, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/55 (2006.01); C07K 14/715 (2006.01);
U.S. Cl.
CPC ...
C07K 14/55 (2013.01); C07K 14/7155 (2013.01); C07K 2319/30 (2013.01); C07K 2319/32 (2013.01); C07K 2319/33 (2013.01);
Abstract
The present invention includes proteins, nucleic acids and methods of making and using an activatable interleukin-2 (aIL2) comprising an Interleukin-2 (aIL2) fusion protein comprising: an Interleukin-2 (IL2) wild-type or mutein; a first cleavable linker; an interleukin-2 receptor binding region (IL2RB), and a half-life extender, such as an antibody Fc region, wherein cleavage of the cleavable linker releases the IL2 from the interleukin-2 receptor beta binding region.