IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11597717 B1

PDFFull Text
Date of Patent:
Mar. 07, 2023

Filed:

Sep. 29, 2021

Substituted imidazoles as plxdc2 ligands

Applicant:

Landos Biopharma, Inc., Blacksburg, VA (US);

Inventors:

Josep Bassaganya-Riera, Blacksburg, VA (US);

Andrew Leber, Blacksburg, VA (US);

Raquel Hontecillas, Blacksburg, VA (US);

Nuria Tubau-Juni, Blacksburg, VA (US);

Assignee:

Landos Biopharma, Inc., Blacksburg, VA (US);

Attorneys:

Daniel A. Blasiole

DeWitt LLP

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
A61K 31/4164 (2006.01); C07D 233/90 (2006.01); C07D 401/12 (2006.01); A61P 37/00 (2006.01); A61P 19/02 (2006.01); A61P 35/04 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61P 19/02 (2018.01); A61P 35/04 (2018.01); A61P 37/00 (2018.01); C07D 405/12 (2013.01);
Abstract

Provided are compounds of Formula Y-Z: The compounds target plexin domain containing 2 (PLXDC2). The compounds can be used to treat conditions such as inflammatory or immune-mediated diseases, diabetes, infectious diseases, and cancers. The compounds can be used to treat such specific conditions as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, autoimmune encephalitis, diabetic nephropathy, diabetic retinopathy, psoriasis, and inflammatory bowel disease, among other conditions.

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