2,4-diaminoquinazoline derivatives and medical uses thereof

Abstract

This application relates to quinazoline derivatives of formula (I), pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds of formula (I) in the treatment or prevention of a viral infection, of a virus-induced disease, of cancer or of an allergy. In formula (I), Ris a Calkyl, optionally substituted by one or more substituents independently selected from fluorine, hydroxyl, amino, nitrile, ester, amide, Calkyl, or Calkoxy, the carbon of Rbonded to the amine in the 4-position of the quinazoline is in (R)-configuration, Ris hydrogen, deuterium, fluorine, chlorine, methyl, methoxy, cyclopropyl, trifluoromethyl, or carboxylic amide, wherein each of methyl, methoxy and cyclopropyl is optionally substituted by one or more substituents independently selected from fluorine and nitrile, Ris hydrogen or deuterium, Ris hydrogen, deuterium, fluorine, methyl, carboxylic ester, carboxylic amide, nitrile, cyclopropyl, Cheterocycle, or 5-membered heteroaryl group, wherein each of methyl, cyclopropyl, Cheterocycle and 5-membered heteroaryl group is optionally substituted by one or more substituents independently selected from fluorine, hydroxyl, or methyl, Ris hydrogen, deuterium, fluorine, chlorine, methyl, or methoxy, provided that at least one of R, R, Rand Ris not hydrogen.