The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2023
Filed:
Oct. 31, 2018
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Zhen Li, Westfield, NJ (US);
Xiaokai Li, Middleton, WI (US);
Erik W. Bush, Verona, WI (US);
Rui Zhu, San Diego, CA (US);
Dongxu Shu, Madison, WI (US);
Jonathan Benson, Stoughton, WI (US);
Patrick Shao, Fanwood, NJ (US);
Matthew Fowler-Watters, Madison, WI (US);
Arrowhead Pharmaceuticals, Inc., Pasadena, CA (US);
Abstract
Synthetic αvβ6 integrin ligands of Formula I having serum stability and affinity for integrin αvβ6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin αvβ6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include αvβ6 integrin ligands and methods of use are also described.