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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11597699 B1

PDFFull Text
Date of Patent:
Mar. 07, 2023

Filed:

Apr. 20, 2020

Mek inhibitors and methods of their use

Applicant:

Exelixis, Inc., Alameda, CA (US);

Inventors:

Naing Aay, San Mateo, CA (US);

Neel Kumar Anand, San Mateo, CA (US);

Charles M. Blazey, San Francisco, CA (US);

Owen Joseph Bowles, Pacifica, CA (US);

Joerg Bussenius, San Mateo, CA (US);

Simona Costanzo, Redwood City, CA (US);

Jeffry Kimo Curtis, San Anselmo, CA (US);

Steven Charles DeFina, Oakland, CA (US);

Larisa Dubenko, San Francisco, CA (US);

Anagha Abhijit Joshi, Fremont, CA (US);

Abigail R. Kennedy, Oakland, CA (US);

Angie Inyoung Kim, San Mateo, CA (US);

Elena S. Koltun, Foster City, CA (US);

Jean-Claire Limun Manalo, Daly City, CA (US);

Csaba J. Peto, Alameda, CA (US);

Kenneth D. Rice, San Rafael, CA (US);

Tsze H. Tsang, El Cerrito, CA (US);

Assignee:

Exelixis, Inc., Alameda, CA (US);

Attorneys:

Honigman LLP

Heidi M. Berven

Andrew S. Chipouras

Primary Examiner:

Po-Chih Chen

Int. Cl.
CPC ...
C07D 205/04 (2006.01); C07D 205/06 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 409/06 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 401/04 (2006.01); C07D 409/12 (2006.01);
U.S. Cl.
CPC ...
C07D 205/04 (2013.01); C07D 205/06 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/06 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01);
Abstract

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

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