IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11596876 B1

PDFFull Text
Date of Patent:
Mar. 07, 2023

Filed:

Feb. 05, 2019

Channeled fibers in separation of biologically active nanoparticles

Applicant:

Clemson University Research Foundation, Clemson, SC (US);

Inventors:

R. Kenneth Marcus, Clemson, SC (US);

Terri F. Bruce, Clemson, SC (US);

Lei Wang, Clemson, SC (US);

Sisi Huang, Clemson, SC (US);

Tyler Y. Slonecki, Clemson, SC (US);

Rhonda Reigers Powell, Clemson, SC (US);

Assignee:

Clemson University Research Foundation, Clemson, SC (US);

Attorney:

Dority & Manning, P.A.

Primary Examiner:

Shafiqul Haq

Int. Cl.
CPC ...
B01D 15/32 (2006.01); G01N 30/00 (2006.01); C07K 14/47 (2006.01); C12N 9/00 (2006.01); C12N 15/10 (2006.01); G01N 1/40 (2006.01); G01N 33/50 (2006.01); A61K 35/68 (2006.01); B01J 20/26 (2006.01); B01J 20/28 (2006.01); B01J 20/285 (2006.01); B01J 20/286 (2006.01);
U.S. Cl.
CPC ...
B01D 15/327 (2013.01); C07K 14/47 (2013.01); C12N 9/00 (2013.01); C12N 15/10 (2013.01); C12N 15/1017 (2013.01); G01N 1/405 (2013.01); G01N 33/5005 (2013.01); A61K 35/68 (2013.01); B01J 20/262 (2013.01); B01J 20/285 (2013.01); B01J 20/286 (2013.01); B01J 20/28023 (2013.01); B01J 2220/54 (2013.01);
Abstract

A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)

Find Patent Forward Citations

Loading…