The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2023
Filed:
Dec. 03, 2019
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Bernhard Hubert Geierstanger, San Diego, CA (US);
Weijia Ou, San Diego, CA (US);
Tetsuo Uno, San Diego, CA (US);
Assignee:
Novartis AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C07K 16/32 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6817 (2017.08); A61K 47/6803 (2017.08); A61K 47/6855 (2017.08); A61K 47/6871 (2017.08); C07K 16/32 (2013.01); C07K 16/2863 (2013.01); C07K 2317/24 (2013.01); C07K 2317/73 (2013.01); C07K 2317/94 (2013.01);
Abstract
The present invention provides specific sites for modifying antibodies or antibody fragments by replacing at least one native amino acid in the constant region of a parental antibody or antibody fragment with cysteine, which can be used as a site of attachment for a payload or linker-payload combination.