The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2023
Filed:
Jul. 12, 2017
Applicant:
Duke University, Durham, NC (US);
Inventors:
Nicholas Scott Heaton, Durham, NC (US);
Alfred Theodore Harding, Durham, NC (US);
Brook Elizabeth Heaton, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); A61K 39/145 (2006.01); A61P 31/16 (2006.01); C07K 14/11 (2006.01); C07K 14/005 (2006.01); C07K 14/00 (2006.01); A61K 39/12 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 39/39 (2006.01); C12N 9/24 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/145 (2013.01); A61K 39/12 (2013.01); A61K 39/39 (2013.01); A61P 31/16 (2018.01); C07K 14/00 (2013.01); C07K 14/005 (2013.01); C07K 14/11 (2013.01); C12N 7/00 (2013.01); C12N 9/2402 (2013.01); C12N 15/86 (2013.01); A61K 2039/5252 (2013.01); C07K 2319/42 (2013.01); C07K 2319/50 (2013.01); C07K 2319/60 (2013.01); C12N 2760/16121 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16143 (2013.01); C12Y 302/01018 (2013.01);
Abstract
Engineered Influenza polynucleotides, viruses, vaccines, and methods of making and using the same are provided. More specifically, the present inventors have developed replication competent engineered influenza viruses having, for example, a modified segment 4 and/or segment 6 that include at least one additional polynucleotide encoding a heterologous polypeptide.