The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 07, 2023
Filed:
Mar. 05, 2020
Revolution Medicines, Inc., Redwood City, CA (US);
Robert J. Nichols, Redwood City, CA (US);
Mark A. Goldsmith, Redwood City, CA (US);
Christopher Schulze, Redwood City, CA (US);
Jacqueline Smith, Redwood City, CA (US);
David E. Wildes, Redwood City, CA (US);
Stephen Kelsey, Redwood City, CA (US);
Mallika Singh, Redwood City, CA (US);
Revolution Medicines, Inc., Redwood City, CA (US);
Abstract
The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.