The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 2023

Filed:

Nov. 22, 2017
Applicant:

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Inventors:

Charles N. Serhan, Needham, MA (US);

Nan Chiang, Boston, MA (US);

Paul Norris, Boston, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/86 (2006.01); A61B 5/15 (2006.01); G01N 30/72 (2006.01); G01N 33/92 (2006.01); G01N 33/96 (2006.01); G01N 30/02 (2006.01);
U.S. Cl.
CPC ...
G01N 33/86 (2013.01); A61B 5/150755 (2013.01); G01N 30/7233 (2013.01); G01N 33/92 (2013.01); G01N 33/96 (2013.01); G01N 2030/027 (2013.01);
Abstract

Disclosed herein is a method of providing a metabololipidomic profile and SPM signature on the progress of the innate host defense response following blood clotting. The method can include the step of taking one or more measurements in a patient's blood sample, wherein the sample is obtained during the time-course of clotting or coagulation or following clotting or coagulation, of pro-thrombotic and pro-inflammatory mediators (eicosanoids) and specialized pro-resolving mediators SPMs. From these measurements, a personalized metabololipidomic profile can be obtained. By comparing the measurement to that taken from normal or reference blood, a comparison profile can be developed. The profile comparison profile can then be used to make a medical or therapeutic decision.


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