The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2023
Filed:
Sep. 13, 2017
Applicant:
The Governors of the University of Alberta, Edmonton, CA;
Inventors:
Rakesh Bhat, Edmonton, CA;
Michael Houghton, Edmonton, CA;
Assignee:
The Governors of the University of Alberta, Edmonton, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); C12N 15/79 (2006.01); A61K 48/00 (2006.01); C07H 21/04 (2006.01); C12N 5/077 (2010.01); C07K 14/705 (2006.01); C12N 15/86 (2006.01); G01N 27/26 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); C07K 14/705 (2013.01); C12N 15/86 (2013.01); G01N 27/26 (2013.01); G01N 33/5061 (2013.01); C07H 21/04 (2013.01); C12N 15/63 (2013.01); C12N 2503/02 (2013.01); C12N 2510/00 (2013.01); G01N 33/6872 (2013.01);
Abstract
Provided herein are recombinant cardiomyocytes and cardiomyocyte cell lines expressing human Ether-a-go-go Related Gene (hERG) potassium ion channel, including, for example, stable cell lines, that comprise a transfected or transduced nucleic acid sequence encoding hERG. Also provided herein are methods of using the recombinant cardiomyocytes and cardiomyocyte cell lines expressing hERG for screening compounds for cardiotoxicity, including methods for determining the activity of compounds to inhibit hERG.