The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2023
Filed:
Mar. 20, 2018
Applicant:
Roche Innovation Center Copenhagen A/s, Hørsholm, DK;
Inventors:
Assignee:
Roche Innovation Center Copenhagen A/S, Horsholm, DK;
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C07H 1/00 (2006.01); C07H 19/10 (2006.01);
U.S. Cl.
CPC ...
C07H 21/04 (2013.01); C07H 1/00 (2013.01); C07H 19/10 (2013.01);
Abstract
The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers comprising an amine containing chiral auxiliary group, and methods of orthogonally protecting the nitrogen of chiral auxiliaries during oligonucleotide synthesis, preventing post elongation chain cleavage, increasing yield and purity of stereodefined phosphorothioate oligonucleotides.