The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2023
Filed:
Mar. 05, 2020
Applicant:
Barry University, Miami Shores, FL (US);
Inventor:
John Boulos, Miami Lakes, FL (US);
Assignee:
BARRY UNIVERSITY, Miami Shores, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 409/06 (2006.01); C07D 413/06 (2006.01); C07D 471/08 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07D 413/06 (2013.01); C07D 409/06 (2013.01); C07D 471/08 (2013.01); A61K 9/0029 (2013.01); A61K 9/0053 (2013.01);
Abstract
Novel Gi/o-biased muscarinic agonists selectively activate only one specific signaling pathway and are novel pharmacophores for development of new painkillers (analgesics). Methods of making and using these agonists are also described. The muscarinic agonists are of the formula: or an analog, derivative or pharmaceutically acceptable salt thereof, wherein: R=H or Me; R=H, Me, Et, OMe, OEt, F, Cl, Br, I, or NO; and R=H, Me, Et, OMe, or COMe (Rmay be bonded to any carbon of the rings).