The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2023
Filed:
Feb. 19, 2021
Applicant:
Afferent Pharmaceuticals, Inc., San Mateo, CA (US);
Inventors:
Ronald Charles Hawley, San Mateo, CA (US);
Prabha Ibrahim, San Mateo, CA (US);
Anthony P. Ford, Palto Alto, CA (US);
Joel R. Gever, Palo Alto, CA (US);
Assignee:
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/12 (2006.01); C07D 417/12 (2006.01); C07D 403/06 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01); A61P 13/00 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01);
Abstract
Disclosed herein are substituted pyrazole-pyrimidine compounds of Formula I and variants thereof for the treatment, for example, of diseases associated with P2X purinergic receptors: In one embodiment, the P2X3 and/or P2X2/3 antagonists disclosed herein are potentially useful, for example, for the treatment of visceral organ, cardiovascular and pain-related diseases, conditions and disorders.