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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11591295 B1

PDFFull Text
Date of Patent:
Feb. 28, 2023

Filed:

Nov. 24, 2020

Affinity illudofulvene conjugates

Applicant:

AF Chemicals, Llc, San Diego, CA (US);

Inventor:

Michael Kelner, San Diego, CA (US);

Assignee:

AF CHEMICALS LLC, San Diego, CA (US);

Attorney:

Sci-Law Strategies PC

Primary Examiner:

Bethany P Barham

Assistant Examiner:

Peter Anthopolos

Int. Cl.
CPC ...
C07C 317/44 (2006.01); C07C 271/34 (2006.01); C07C 309/72 (2006.01); C07C 311/16 (2006.01); C07D 207/444 (2006.01); A61K 31/27 (2006.01); C07K 5/083 (2006.01); C07K 5/062 (2006.01); C07C 225/14 (2006.01); A61K 31/215 (2006.01); A61K 31/265 (2006.01); A61K 31/255 (2006.01); A61K 38/06 (2006.01); A61K 38/05 (2006.01); A61K 31/4015 (2006.01); A61K 47/54 (2017.01); C07C 205/42 (2006.01);
U.S. Cl.
CPC ...
C07C 317/44 (2013.01); A61K 31/215 (2013.01); A61K 31/255 (2013.01); A61K 31/265 (2013.01); A61K 31/27 (2013.01); A61K 31/4015 (2013.01); A61K 38/05 (2013.01); A61K 38/06 (2013.01); A61K 47/554 (2017.08); C07C 205/42 (2013.01); C07C 225/14 (2013.01); C07C 271/34 (2013.01); C07C 309/72 (2013.01); C07C 311/16 (2013.01); C07D 207/444 (2013.01); C07K 5/06026 (2013.01); C07K 5/06052 (2013.01); C07K 5/0806 (2013.01); C07C 2603/94 (2017.05);
Abstract

In an embodiment of the invention, a composition for treating a cell population comprises a medicant. The medicant moiety can be an illudofulvene analog. In an embodiment of the invention, a composition for treating a cell population comprises an Affinity Medicant Conjugate (AMC). The affinity moiety can be an antibody, an antibody fragment, a receptor protein, a peptidic growth factor, an anti-angiogenic protein, a specific binding peptide, protease cleavable peptide, a glycopeptide, a peptide, a peptidic toxin, a protein toxin and an oligonucleotide. The affinity moiety can be covalently bound to the medicant via a linker.

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