The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 2023

Filed:

Oct. 26, 2018
Applicant:

Medibeacon Inc., St. Louis, MO (US);

Inventors:

Raghavan Rajagopalan, Solon, OH (US);

Richard B. Dorshow, St. Louis, MO (US);

William L. Neumann, St. Louis, MO (US);

Thomas E. Rogers, St. Louis, MO (US);

Martin P. Debreczeny, Berkeley, CA (US);

Assignee:

MediBeacon Inc., St. Louis, MO (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61K 49/00 (2006.01); A61M 5/00 (2006.01); A61B 5/00 (2006.01); A61B 5/20 (2006.01); C09B 57/00 (2006.01); A61P 13/12 (2006.01); C09K 11/06 (2006.01); C07D 241/26 (2006.01);
U.S. Cl.
CPC ...
A61K 49/0021 (2013.01); A61B 5/0071 (2013.01); A61B 5/201 (2013.01); A61K 49/0004 (2013.01); A61K 49/0054 (2013.01); A61M 5/007 (2013.01); A61P 13/12 (2018.01); C09B 57/00 (2013.01); C09K 11/06 (2013.01); C07D 241/26 (2013.01); C09K 2211/1077 (2013.01);
Abstract

The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The method includes administering a pyrazine compound of Formula I to a patient and monitoring the rate in which the kidneys of the patient eliminate the pyrazine from the systemic circulation of the patient. The pyrazine compound fluoresces when exposed to electromagnetic radiation which is detected using one or more sensors. The rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.


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