logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11590223 B1

PDFFull Text
Date of Patent:
Feb. 28, 2023

Filed:

Aug. 30, 2019

Dosing strategy that mitigates cytokine release syndrome for therapeutic antibodies

Applicant:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

Carrie Brownstein, New York, NY (US);

Israel Lowy, Dobbs Ferry, NY (US);

Lieve Lucille Adriaens, Westfield, NJ (US);

Assignee:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Attorneys:

Schwabe, Williamson & Wyatt PC

Aparna Patankar

Primary Examiner:

Bridget E Bunner

Assistant Examiner:

Fozia M Hamud

Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61P 35/00 (2006.01); A61K 31/405 (2006.01); A61K 31/573 (2006.01); A61K 45/06 (2006.01); C07K 16/24 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 31/405 (2013.01); A61K 31/573 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 16/248 (2013.01); C07K 16/2809 (2013.01); C07K 16/2818 (2013.01); C07K 16/2866 (2013.01); C07K 16/2887 (2013.01); A61K 2039/507 (2013.01); A61K 2039/545 (2013.01); C07K 2317/31 (2013.01);
Abstract

Administration regimens for therapeutic proteins (e.g., T cell-activating bispecific antibodies) that mitigate cytokine release syndrome and infusion-related reaction are disclosed. The methods employ initial fractional dosing with optional administration of additional agents such as steroids or cytokine antagonists that are discontinued with maximal weekly dosing over the course of the dosing regimen.

Find Patent Forward Citations

Brownstein, Carrie. (2023). Dosing strategy that mitigates cytokine release syndrome for therapeutic antibodies (U.S. Patent No. 11590223). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11590223

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…