The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2023
Filed:
Nov. 19, 2020
The Johns Hopkins University, Baltimore, MD (US);
William R. Bishai, Baltimore, MD (US);
Ruchi Jain Dey, Baltimore, MD (US);
Bappaditya Dey, Baltimore, MD (US);
Laurene Cheung, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
The present invention includes the discovery of a strain ofcomprising an expression vector encoding a di-adenylate cyclase enzyme. Theis selected from the group consisting of, or a combination thereof and the preferred strain ofis BCG. The preferred expression vector is a mycobacterial expression vector including an hsp60 promoter and a DNA sequence of diadenylate cyclase (disA), or a functional part thereof. The strains ofare used in therapeutic applications including tuberculosis and cancer.