The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 28, 2023
Filed:
Nov. 30, 2018
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
The Regents of the University of California, Oakland, CA (US);
Friedrich-alexander-universität Erlangen-nürnberg, Erlangen, DE;
Roger Sunahara, San Diego, CA (US);
Harald Huebner, Heroldsbach, DE;
Jeremy Shonberg, Symonston, AU;
Anne Stößel, Fürth, DE;
Markus Stanek, Uttenreuth, DE;
Dorothée Möller, Erlangen, DE;
Mary Joyce Clark, La Jolla, CA (US);
Brian K. Kobilka, Stanford, CA (US);
Peter Gmeiner, Erlangen, DE;
Luis Maul, Erlangen, DE;
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Stanford, CA (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, DE;
Abstract
Aspects of the present disclosure include conformationally restricted analogs of catecholamine type compounds (e.g., isoprenaline, adrenaline, noradrenaline) which activate β2AR with high selectivity over β1AR. The subject beta-2 selective adrenergic receptor agonist compounds may serve as bronchiodilators and find use in the treatment of a variety of bronchoconstrictive diseases and conditions. Also provided are compositions and methods for treating preterm labor. A method of treating acute asthma including administration of a subject compound to a subject in need thereof is provided. The subject method can provide for reduced undesirable side effects associated with non-selective β-adrenergic receptor agonism, such as inotropic and chronotropic effects that leads to elevated blood pressure. The compounds can also be used to prevent or treat heart failure. Kits and compositions for practicing the subject methods are also provided.