Generating computer models from implicitly relevant feature sets

Abstract

Mechanisms are provided for training a hybrid machine learning (ML) computer model to simulate a biophysical system of a patient and predict patient classifications based on results of simulating the biophysical system. A mechanistic model is executed to generate a training dataset. A surrogate ML model is trained to replicate logic of the mechanistic computer model and generate patient feature outputs based on surrogate ML model input parameters. A transformation ML model is trained to transform patient feature outputs of the surrogate ML model into a distribution of patient features. A generative ML model is trained to encode samples from a uniform distribution of input patient data into mechanistic model parameter inputs that are coherent to the target distribution of patient features and are input to the surrogate ML model. Input patient data for a patient is processed through the ML models to predict a patient classification for the patient.