The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2023
Filed:
Apr. 13, 2021
Byondis B.v., Nijmegen, NL;
Miranda Maria Cornelia Van Der Lee, Nijmegen, NL;
Gerardus Joseph Andreas Ariaans, Nijmegen, NL;
Jan Schouten, Nijmegen, NL;
Marion Blomenrohr, Nijmegen, NL;
Patrick Gerhard Groothuis, Nijmegen, NL;
Rudy Gerardus Elisabeth Coumans, Nijmegen, NL;
Byondis B.V., Nijmegen, NL;
Abstract
The present invention relates to antibodies against the human 5T4 oncofoetal antigen and corresponding antibody-drug conjugates that are suitable for testing in clinical trials. The antibodies are cross-reactive for humans and cynomolgus monkeys and exhibit an affinity for human 5T4 antigen which is in the same order of magnitude as their affinity for cynomolgus monkey 5T4 antigen. The invention further relates to the use of the antibodies and corresponding ADCs in the treatment of solid tumours and haematological malignancies.