The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2023
Filed:
Jun. 23, 2016
Applicant:
Cytodyn Inc., Vancouver, WA (US);
Inventor:
Denis R. Burger, Vancouver, WA (US);
Assignee:
Cytodyn Inc., Vancouver, WA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 31/439 (2006.01); A61P 37/06 (2006.01); A61P 31/12 (2006.01); A61K 39/00 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2866 (2013.01); A61K 31/439 (2013.01); A61P 25/28 (2018.01); A61P 31/12 (2018.01); A61P 37/06 (2018.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01);
Abstract
Methods for the therapeutic use of competitive inhibitors of the CCR5/CCL5 axis that express antagonist activity for RANTES (CCL5) for immunomodulatory treatment of subjects in need thereof. The competitive inhibitors may not have CCL5 agonist activity and can be used to inhibit, interrupt, block, mitigate, slow the progress of, and/or treat inflammation and/or various other CCR5/CCL5 axis signaling dependent down-stream activities associated with transplantation, including graft versus host disease, autoimmune disorders, infectious agents, chronic inflammation, and cancer, etc.