The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2023
Filed:
Sep. 12, 2018
Applicant:
Vilnius University, Vilnius, LT;
Inventors:
Assignee:
VILNIUS UNIVERSITY, Vilnius, LT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/10 (2006.01); C12Q 1/68 (2018.01); C07H 21/04 (2006.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
C07H 19/10 (2013.01); C07H 21/04 (2013.01); C12N 15/1075 (2013.01); C12Q 1/68 (2013.01);
Abstract
Disclosed are W-position modified cytidine nucleotides of formula (I). Provided herein are methods of chemical synthesis of AP-modified cytidine nucleoside triphosphates and their applications as well as uses of the cytidine analogues for the synthesis of modified nucleic acids. The nucleic acid molecule includes DNA, RNA or a combination of DNA/RNA. One of many applications of modified cytidine nucleotides described herein is enzyme selection, when an enzyme of interest bears an activity of an esterase, amidase, oxidoreductase, lyase, ligase or other enzymatic activity, formula (I) wherein the substituants are as defined in the appended claims.