The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2023
Filed:
Aug. 13, 2018
Applicant:
Global Blood Therapeutics, Inc., South San Francisco, CA (US);
Inventors:
Ming Yu, Foster City, CA (US);
Zhe Li, San Diego, CA (US);
Qing Xu, Foster City, CA (US);
Calvin Yee, Daly City, CA (US);
Lina Setti, Fremont, CA (US);
Hing Sham, Palo Alto, CA (US);
Assignee:
Global Blood Therapeutics, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 221/06 (2006.01); C07D 221/22 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 221/06 (2013.01); C07D 221/22 (2013.01); C07D 401/14 (2013.01); C07D 471/04 (2013.01);
Abstract
The present disclosure provides tricyclic compounds of formula (I) that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.