The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2023
Filed:
Sep. 28, 2020
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Assignee:
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 495/14 (2006.01); A61K 47/54 (2017.01); C07J 43/00 (2006.01); C07D 487/04 (2006.01); C07D 471/04 (2006.01); C07D 401/14 (2006.01); A61K 31/454 (2006.01); C07J 3/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/542 (2017.08); A61K 31/454 (2013.01); A61K 47/54 (2017.08); A61K 47/545 (2017.08); A61K 47/549 (2017.08); A61K 47/554 (2017.08); C07D 401/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 495/14 (2013.01); C07J 43/003 (2013.01); C07J 3/005 (2013.01);
Abstract
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof.