The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2023
Filed:
Feb. 17, 2017
Applicant:
Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Lois Smith, West Newton, MA (US);
Jean-Sebastien Joyal, Boston, MA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/513 (2006.01); A61K 31/352 (2006.01); A61K 31/519 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 31/513 (2013.01); A61K 31/352 (2013.01); A61K 31/519 (2013.01); G01N 33/5044 (2013.01); G01N 2800/164 (2013.01); G01N 2800/50 (2013.01);
Abstract
The instant invention provides methods and compositions related to discovery of Free Fatty Acid Receptor 1 (FFA1) as a therapeutic target for treatment or prevention of diseases or disorders of neurons that are characterized by angiogenesis, or of vascular diseases of the eye, retinal degeneration and/or tumors more generally. Therapeutic and/or prophylactic uses and compositions of known FFA1 inhibitors, including small molecules and nucleic acid agents, are described. Methods for identification of novel FFA1 inhibitors are also provided.