The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 14, 2023

Filed:

Dec. 12, 2017
Applicants:

Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;

Neuroindx, Inc., Torrance, CA (US);

The Foundation for the Promotion of Industrial Science, Tokyo, JP;

Inventors:

Dominique Collard, Lambersart, FR;

Hiroyuki Fujita, Tokyo, JP;

Stanislav Karsten, Rancho Palos Verdes, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 15/10 (2006.01); B01L 3/00 (2006.01); G01N 3/08 (2006.01); G01N 33/487 (2006.01); G01N 3/32 (2006.01); G01N 1/10 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1056 (2013.01); B01L 3/502761 (2013.01); G01N 3/08 (2013.01); G01N 3/32 (2013.01); G01N 15/1031 (2013.01); G01N 33/48728 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0627 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0867 (2013.01); B01L 2400/049 (2013.01); G01N 2001/1056 (2013.01); G01N 2015/105 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1081 (2013.01); G01N 2015/1093 (2013.01); G01N 2203/0089 (2013.01); G01N 2203/0286 (2013.01);
Abstract

The invention relates to a system () adapted to measure multiple biophysical characteristics of cells, the system () comprising: a microfluidic chip () provided with a microfluidic channel () which allows cells to flow through, the microfluidic channel () having an inlet (), an outlet (), and a lateral opening () situated between the inlet () and the outlet (); and a capacitive sensor () integrated in the microfluidic chip, adapted to obtain biophysical characteristics of a single cell in the microfluidic channel () by directly manipulating the single cell by sensor elements () through the lateral opening () of the microfluidic channel (), the sensor () comprising a stationary part and an electrostatically driven movable part which is movable relative to the stationary part, the stationary part being fixed to the microfluidic chip (), the movable part being arranged in the lateral opening () of the microfluidic channel (), wherein a portion of the sensor elements () provides an interface between fluid and air in the system.


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