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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11579051 B1

PDFFull Text
Date of Patent:
Feb. 14, 2023

Filed:

Mar. 11, 2020

Stable dithizone solutions and formulations and methods for their use

Applicant:

City of Hope, Duarte, CA (US);

Inventors:

Ismail H. Al-Abdullah, Azusa, CA (US);

Meirigeng Qi, Duarte, CA (US);

Bashar Khiatah, Duarte, CA (US);

Luis Valiente, Burbank, CA (US);

Assignee:

CITY OF HOPE, Duarte, CA (US);

Attorneys:

Perkins Coie LLP

Lara J. Dueppen

Primary Examiner:

Sudhakar Katakam

Assistant Examiner:

Jennifer C Sawyer

Int. Cl.
CPC ...
C07C 337/06 (2006.01); G01N 1/30 (2006.01);
U.S. Cl.
CPC ...
G01N 1/30 (2013.01); C07C 337/06 (2013.01); G01N 2001/302 (2013.01);
Abstract

An optimized Dipheylthiocarbazone or Dithizone (DTZ) solution was developed with preferred physical and chemical properties to characterize human islets and insulin producing cells differentiated from embryonic stem cells. Application of the newly formulated iDTZ (i stands for islet) over a range of temperatures, time intervals and cell and tissue types found to be robust for identifying these cells. The iDTZ, through high transition zinc binding, concentrated in insulin producing cells could also be used to delineate zinc levels in tissue and liquid samples.

Find Patent Forward Citations

Al-Abdullah, Ismail. (2023). Stable dithizone solutions and formulations and methods for their use (U.S. Patent No. 11579051). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11579051

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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