The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2023
Filed:
Feb. 14, 2018
Applicant:
Institute for Cancer Research, Philadelphia, PA (US);
Inventors:
Sanjeevani Arora, Philadelphia, PA (US);
Joshua Meyer, Philadelphia, PA (US);
Erica Golemis, Philadelphia, PA (US);
Randy Lesh, Philadelphia, PA (US);
Assignee:
Institute For Cancer Research, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 31/00 (2006.01); G01N 33/53 (2006.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01); C12Q 1/68 (2018.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12Q 1/68 (2013.01); G01N 33/57407 (2013.01); G01N 33/57423 (2013.01); G01N 33/57434 (2013.01); G01N 33/57488 (2013.01); G01N 33/6875 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01);
Abstract
Methods for diagnosing a subject as a candidate for removal of a solid tumor without preoperative chemoradiation therapy, and methods for treating patients having solid tumors, who have one or more of genomic instability, elevated double stranded DNA breaks, elevated gamma-H2AX foci, or elevated replication stress and/or double stranded break-signalling (DSB-signalling) biomarkers in peripheral blood lymphocytes (PBLs) are provided herein.