The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2023
Filed:
Dec. 12, 2019
Applicant:
Synthetic Genomics, Inc., La Jolla, CA (US);
Inventors:
June Elizabeth Pais, San Diego, CA (US);
Roberto Spreafico, La Jolla, CA (US);
Assignee:
Viridos, Inc., La Jolla, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/10 (2006.01); C12N 15/90 (2006.01); A01H 13/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1007 (2013.01); C12N 15/902 (2013.01); C12Y 201/01037 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01);
Abstract
The present application relates to the identification of novel DNA methyltransferases including CHG methylation in algal species. The present application relates to algal mutants permitting the expression of exogenous genes by alleviating the epigenetic mechanisms of CHG and CHH methylation of exogenous DNA and mono- and tri-methylation of lysine 9 of histone 3 (H3K9). This is achieved by mutating or attenuating the methyltransferase (MTase) genes in algae. The present application also relates to methods for efficiently expressing exogenous genes in algal species.