The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 14, 2023

Filed:

Nov. 06, 2018
Applicants:

Fraunhofer-gesellschaft Zur Förderung Der Angewandten Forschung E. V., Munich, DE;

Universität Regensburg, Regensburg, DE;

Inventors:

Joachim Wegener, Laaber, DE;

Carina Schmittlein, Regensburg, DE;

Michael Skiba, Regensburg, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/42 (2006.01); C12M 1/12 (2006.01); C12M 1/34 (2006.01); C12M 1/36 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12M 35/02 (2013.01); C12M 25/02 (2013.01); C12M 41/46 (2013.01); C12M 41/48 (2013.01); G01N 33/5008 (2013.01);
Abstract

The invention relates to a device designed for the cultivation and radiation-induced killing of living biological cells. The device comprises a flat substrate and a functional layer for creating a wound in biological cells, said functional layer being applied to the flat substrate. The functional layer contains at least one photosensitizer which is designed to convert triplet oxygen into singlet oxygen by the application of electromagnetic radiation. As a result, biological cells on the functional layer can be killed by irradiation of low-intensity electromagnetic radiation. A wound can be introduced into a cell layer at a locally defined point easily, quickly, carefully, and in a flexible and cost-effective manner and thus the healing of the wound can be studied. The invention further relates to uses of the devices and a method for analyzing a migration and/or wound healing behavior of biological cells.


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