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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11578109 B1

PDFFull Text
Date of Patent:
Feb. 14, 2023

Filed:

Jul. 12, 2018

Universal vaccine based on shared tumor neoantigens for prevention and treatment of micro satellite instable (msi) cancers

Applicant:

Nouscom Ag, Basel, CH;

Inventors:

Alfredo Nicosia, Naples, IT;

Elisa Scarselli, Rome, IT;

Guido Leoni, Rome, IT;

Armin Lahm, Rom, IT;

Assignee:

NOUSCOM AG, Basel, CH;

Attorney:

McDonnell Boehnen Hulbert & Berghoff, LLP

Primary Examiner:

Thea D' Ambrosio

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 35/00 (2006.01); A61K 38/16 (2006.01); A61K 38/10 (2006.01); A61K 38/08 (2019.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A61K 38/04 (2006.01); C07K 14/47 (2006.01); G16B 20/00 (2019.01); A61K 39/00 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4748 (2013.01); A61K 38/04 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 38/16 (2013.01); A61K 39/0011 (2013.01); C07K 7/00 (2013.01); C12N 15/00 (2013.01); G16B 20/00 (2019.02); A61K 2039/5152 (2013.01);
Abstract

This invention relates to a method of selecting a collection of frame-shift peptides (CFSPs) to produce a universal cancer vaccine peptide collection (CVP) for prophylaxis and treatment of patients with hereditary and sporadic micro-satellite instability (MSI) tumors. This invention relates as well to a method of producing a CVP by selecting a subset of frame-shift peptides (FSPs) from the CFSP and optionally modifying the FSP's amino acid (aa) sequence to generate modified FSPs (mFSPs). The invention further relates to nucleic acid collections encoding a CVP of FSPs and/or mFSPs in one or more vaccine vectors that can be used also simultaneously. These CVPs, nucleic acids and vectors are used for the prophylaxis or treatment of MSI cancers.

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