The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2023
Filed:
Aug. 28, 2020
Pacific Biosciences of California, Inc., Menlo Park, CA (US);
Lubomir Sebo, Redwood City, CA (US);
Jeremiah Hanes, Menlo Park, CA (US);
Gene Shen, Santa Clara, CA (US);
Louis Brogley, Santa Cruz, CA (US);
Stephen Yue, Eugene, OR (US);
Frank Zheng, Fremont, CA (US);
Yuri Lapin, Newark, CA (US);
John Lyle, Fremont, CA (US);
Honey Osuna, San Francisco, CA (US);
Andrei Fedorov, San Bruno, CA (US);
Pacific Biosciences of California, Inc., Menlo Park, CA (US);
Abstract
Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.