The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 14, 2023

Filed:

Nov. 06, 2020
Applicant:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Yan Chen, Foster City, CA (US);

Jiaxin Yu, Foster City, CA (US);

Simon Shaw, Oakland, CA (US);

Ihab Darwish, South San Francisco, CA (US);

Vanessa Taylor, San Francisco, CA (US);

Somasekhar Bhamidipati, Foster City, CA (US);

Zhushou Luo, San Jose, CA (US);

Rao Kolluri, Foster City, CA (US);

Assignee:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 223/16 (2006.01); A61K 31/55 (2006.01); C07D 491/107 (2006.01); A61P 39/00 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 471/08 (2006.01); C07D 471/10 (2006.01);
U.S. Cl.
CPC ...
C07D 491/107 (2013.01); A61P 39/00 (2018.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 471/08 (2013.01); C07D 471/10 (2013.01);
Abstract

Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The compounds may have a structure according to Formula I The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.


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