The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2023
Filed:
Sep. 01, 2020
Applicant:
Ankh Life Sciences Limited, Dublin, IE;
Inventors:
Gene H. Zaid, Hutchinson, KS (US);
Krishna Mohan Donavalli, Wichita, KS (US);
Rajni Verma, Wichita, KS (US);
Assignee:
Ankh Life Sciences Limited, Dublin, IE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); B01J 31/02 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); B01J 31/0209 (2013.01);
Abstract
Methods for the synthesis of harmine comprise reacting harmaline with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in the presence of a diacid catalyst. In an embodiment, the synthesis is carried out using a reaction mixture of harmaline, DDQ, THF solvent, and succinic acid; the reaction is carried out under an inert atmosphere with refluxing for a period of 4-12 hours.