The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2023
Filed:
Jan. 30, 2018
Applicants:
Kyoto University, Kyoto, JP;
Astellas Pharma Inc., Tokyo, JP;
Inventors:
Shimon Sakaguchi, Kyoto, JP;
Naganari Ohkura, Kyoto, JP;
Norihisa Mikami, Kyoto, JP;
Shuh Narumiya, Kyoto, JP;
Masahiko Akamatsu, Tokyo, JP;
Guliang Xia, San Diego, CA (US);
Hironori Harada, Tokyo, JP;
Naoto Nakamura, Tokyo, JP;
Satoru Ujihara, Tokyo, JP;
Hisao Hamaguchi, Tokyo, JP;
Assignees:
KYOTO UNIVERSITY, Kyoto, JP;
ASTELLAS PHARMA INC., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 35/17 (2015.01); C12N 5/0783 (2010.01); A61P 37/08 (2006.01); A61P 29/00 (2006.01); A61P 37/06 (2006.01); A61K 31/437 (2006.01); A61K 31/497 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/437 (2013.01); A61K 31/497 (2013.01); A61K 35/17 (2013.01); A61P 29/00 (2018.01); A61P 37/06 (2018.01); A61P 37/08 (2018.01); C12N 5/0637 (2013.01); C12N 15/11 (2013.01); C12N 2500/38 (2013.01); C12N 2501/04 (2013.01); C12N 2501/15 (2013.01); C12N 2501/999 (2013.01);
Abstract
Provided are a novel compound having CDK8 and/or CDK19 inhibitory activity, and a production method for Tregs. The treatment of T cells with a CDK8 and/or CDK19 inhibitor induces Foxp3 in the T cells. Foxp3T cells can be induced by treating Foxp3T cells with the CDK8 and/or CDK19 inhibitor in vitro. Thus, Tregs can be induced.