The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2023
Filed:
Mar. 15, 2019
Applicant:
Kezar Life Sciences, South San Francisco, CA (US);
Inventor:
Henry Johnson, San Bruno, CA (US);
Assignee:
KEZAR LIFE SCIENCES, South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 255/02 (2006.01); C07D 401/12 (2006.01); C07D 413/14 (2006.01); C07D 403/12 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61P 35/00 (2018.01); C07D 255/02 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 413/14 (2013.01);
Abstract
Provided herein are triazacyclododecansulfonamide ('TCD')-based protein secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I) and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.