The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2023
Filed:
Oct. 04, 2017
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Entrinsic, Inc., Norwood, MA (US);
Sadasivan Vidyasagar, Gainesville, FL (US);
Reshu Gupta, Gainesville, FL (US);
Liangjie Yin, Gainesville, FL (US);
Astrid Grosche, Gainesville, FL (US);
Paul Gerson Okunieff, Gainesville, FL (US);
Stephen Gatto, Norwood, MA (US);
Daniel Dennison, Tallahassee, FL (US);
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., Gainesville, FL (US);
ENTRINSIC, LLC, Norwood, MA (US);
Abstract
The present disclosure provides compositions and methods for promoting stem cell and/or progenitor cell proliferation and/or differentiation. The provided compositions may be useful in treating a disease or condition that is related to mucosal barrier function, e.g., wound healing, treating skin conditions (e.g., atopic dermatitis, psoriasis, bed sores, or condition related to the aging of skin), treating a lung disorders (e.g., asthma), a condition related to improving mucosal barrier function, and/or treating injury to GI mucosa in a subject in need thereof. The present disclosure also provides methods for promoting the proliferation and/or differentiation of stem cells and/or the progenitor cells in a subject in need of such treatment by administering a composition. The ability to stimulate the proliferation and/or differentiation of stem cells and/or the progenitor cells in vivo, ex vivo and/or in vitro provides tremendous benefit. The present disclosure can be used to increase stem cell populations in in vivo, ex vivo and/or in vitro. Stem cell transplantation provides treatments and/or cures of many disease states, degeneration and/or injury.