The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 2023
Filed:
Feb. 05, 2020
Regeneren Pharmaceuticals, Inc., Tarrytown, NY (US);
Yale University, New Haven, CT (US);
Institute for Research IN Biomedicine (Irb), Bellinzona, CH;
Dietmar Herndler-Brandstetter, New Haven, CT (US);
Richard A. Flavell, Guilford, CT (US);
Davor Frleta, Tarrytown, NY (US);
Cagan Gurer, Tarrytown, NY (US);
Markus Gabriel Manz, Zollikon, CH;
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Noah W. Palm, New Haven, CT (US);
Liang Shan, New Haven, CT (US);
Sean Stevens, Del Mar, CA (US);
Till Strowig, Braunschweig, DE;
George D. Yancopoulos, Yorktown Heights, NY (US);
Marcel de Zoete, Amersfoort, NL;
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Yale University, New Haven, CT (US);
Institute for Research in Biomedicine (IRB), Bellinzona, CH;
Abstract
Genetically modified non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome are provided. Also provided are methods for making non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome, and methods for using non-human animals expressing human SIRPα and human IL-15 from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human T cell and/or natural killer (NK) cell development and function, in modeling human pathogen infection of human T cells and/or NK cells, and in various in vivo screens.