The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 07, 2023

Filed:

Dec. 20, 2019
Applicant:

Roche Molecular Systems, Inc., Pleasanton, CA (US);

Inventors:

Kyle C. Cady, Santa Clara, CA (US);

Colin Lam, Redwood City, CA (US);

Jeffrey Alexander, Hayward, CA (US);

Kristina Chu, Pleasanton, CA (US);

Barbara Eckert, El Cerrito, CA (US);

Dylan Goldman, San Jose, CA (US);

Patrick Lin, San Jose, CA (US);

Kalyani Mangipudi, Pleasanton, CA (US);

Misha Mehta, Pleasanton, CA (US);

Arrash Moghaddasi, Sunnyvale, CA (US);

Hai Nguyen, San Jose, CA (US);

Natacha Sorenson, Los Gatos, CA (US);

Assignee:

Roche Molecular Systems, Inc., Pleasanton, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6897 (2018.01); C12N 1/20 (2006.01); C12N 15/70 (2006.01); C12N 15/74 (2006.01); C12Q 1/14 (2006.01); C12Q 1/18 (2006.01); C12Q 1/66 (2006.01); C12Q 1/689 (2018.01);
U.S. Cl.
CPC ...
C12Q 1/6897 (2013.01); C12N 1/20 (2013.01); C12N 15/70 (2013.01); C12N 15/74 (2013.01); C12Q 1/14 (2013.01); C12Q 1/18 (2013.01); C12Q 1/66 (2013.01); C12Q 1/689 (2013.01); C12N 2795/10043 (2013.01); C12N 2795/10152 (2013.01); C12N 2795/10343 (2013.01); C12N 2795/10352 (2013.01); C12Y 113/12007 (2013.01); G01N 2333/31 (2013.01);
Abstract

The present invention relates to compositions comprising and methods of producing genetically engineered bacteriophages, bacteriophage-like particles and non-replicating transduction particles (NRTPs) that contain non-native tail fibers that display altered host specificity and/or reactivity. The present invention also relates to methods of using these bacteriophages and NRTPs for the development of novel diagnostics, therapeutics and/or research reagents for bacteria-related diseases.


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