The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2023
Filed:
Jun. 29, 2018
Universita' Degli Studi Di Firenze, Florence, IT;
Di. V.a.l. Toscana S.r.l., Sesto Fiorentino, IT;
Annarosa Arcangeli, Florence, IT;
Claudia Duranti, Pontassieve, IT;
Laura Carraresi, Florence, IT;
Silvia Crescioli, Florence, IT;
UNIVERSITÀ DEGLI STUDI DI FIRENZE, Sesto Fiorentino, IT;
Abstract
The present invention describes a bispecfic antibody composed of the variable domains (VH and VL) of two antibodies, hERG1 mAb (which binds the extracellular domain S5-P of hERG1) and of β1 integrin mAb TS2/16 or BV7, which bind the extracellular domain of β1 integrin. The present invention relates also to a novel anti-hERG1 molecule bearing a Cys in position 95 of the VH domain. The invention describes also their application for diagnostic and therapeutic purposes in oncology and other fields of medical sciences.