The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2023
Filed:
Feb. 09, 2018
Applicant:
Chiome Bioscience Inc., Tokyo, JP;
Inventors:
Keisuke Niikura, Tokyo, JP;
Yosuke Kamimura, Tokyo, JP;
Assignee:
CHIOME BIOSCIENCE INC., Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12N 5/16 (2006.01);
U.S. Cl.
CPC ...
C07K 16/00 (2013.01); C07K 2317/14 (2013.01); C07K 2317/21 (2013.01); C07K 2317/23 (2013.01); C07K 2317/24 (2013.01);
Abstract
The present invention relates to a method for promoting diversification of variable regions of an antibody. Specifically, the present invention relates to a method for promoting diversification of the amino acid sequences of variable regions of an antibody generated by an avian B cell population, wherein the method comprises suppressing the PI3Kα activity of each avian B cell comprised in the avian B cell population expressing the antibody.