The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2023
Filed:
Nov. 21, 2018
Applicant:
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Inventors:
Douglas Kim, Reston, VA (US);
Karel Svoboda, Leesburg, VA (US);
Loren Looger, Sterling, VA (US);
Eric Schreiter, Ashburn, VA (US);
Assignee:
Howard Hughes Medical Institute, Chevy Chase, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/72 (2006.01); A61K 38/00 (2006.01); C12N 15/85 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C07K 14/723 (2013.01); A61K 38/00 (2013.01); C07K 2319/60 (2013.01); G01N 33/5041 (2013.01);
Abstract
Genetically encoded calcium indicator (GECI) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of G-protein coupled receptor (GPCR) or ion channels and methods of monitoring neural activity also are provided.