The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 07, 2023
Filed:
Aug. 15, 2019
Target Biopharmaceutical Technology Shenzhen Company Limited, Shenzhen, CN;
Yongmei Xie, Shenzhen, CN;
Xiangrong Song, Shenzhen, CN;
Xifei Yang, Shenzhen, CN;
Yu Zhao, Shenzhen, CN;
Bo Luo, Shenzhen, CN;
TARGET BIOPHARMACEUTICAL TECHNOLOGY SHENZHEN COMPANY LIMITED, Shenzhen, CN;
Abstract
The invention relates to novel camptothecin derivatives and their applications, tumor cell growth inhibitors, ternary complexes, and a method for improving the solubility of the camptothecin derivatives. The camptothecin derivatives are prepared by modifying the substance shown as Formula I with glycosylated triazole at position R. In the structure shown as Formula I, Rrepresents H, Calkyl, Calkyl-D or Chaloalkyl; Rrepresents H, CHN(CH)or CHN(CD); and Rrepresents or H, wherein X represents N, O or S; and L represents polypeptide, Clinear alkyl or derivatives thereof, Clinear or branched acyl derivatives, Cethylene glycol or derivatives thereof. The camptothecin derivatives have high solubility, the anticancer drugs prepared from them have the advantages of wide anticancer spectrum and high safety, and have in vivo anticancer activity higher than irinotecan hydrochloride.